Padres vs. Guardians Prediction, Odds, Picks - April 2

Data Skrive

The San Diego Padres and Cleveland Guardians will meet on Wednesday at PETCO Park, at 4:10 p.m. ET, with Manny Machado and Jose Ramirez among those expected to deliver at the plate. The Guardians are +147 moneyline underdogs in this matchup against the favored Padres (-175). San Diego is the run-line favorite (-1.5). The contest’s total is listed at 7.5 runs.

Here is everything you need to know from a betting perspective on the Padres-Guardians game, regarding the run line, moneyline and total, plus expert picks.

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Padres vs. Guardians Game Information & Odds

When: Wednesday, April 2, 2025 at 4:10 p.m. ET
Where: PETCO Park in San Diego, California
How to watch on TV: SDPA and CLEG

Favorite Favorite Moneyline Underdog Moneyline Total Over Total Odds Under Total Odds Run Line Favorite Run Line Odds Underdog Run Line Odds Padres -175 +147 7.5 -102 -118 -1.5 +125 -150

Padres vs. Guardians Prediction

Score Prediction: Padres 5, Guardians 2
Total Prediction: Under 7.5 runs
Win Probabilities: Padres 72%, Guardians 28%

Padres vs. Guardians Betting Insights

The Padres went 64-42 in games they were listed as the moneyline favorite last season (winning 60.4% of those games).
San Diego had a record of 20-10 in games it played as a moneyline favorite with odds of -175 or shorter last year (66.7%).
Based on this matchup’s moneyline, the Padres have an implied win probability of 63.6%.
The Guardians were underdogs 65 times last season and won 29, or 44.6%, of those games.

Padres Player Insights

Machado finished with a .275 average last season, with 29 home runs and 105 RBI.
Jackson Merrill hit .292 with an OBP of .326 and a slugging percentage of .500.
Luis Arraez hit .314 last season with four home runs and 46 RBI.
Jake Cronenworth hit .241 with an OBP of .324, and a slugging percentage of .390.