Knicks vs. Pistons odds, line: Proven model reveals picks for NBA first-round matchup on April 24, 2025

The 2025 NBA Playoffs continue on Thursday when the No. 3 seed New York Knicks travel to take on the No. 6 seed Detroit Pistons for Game 3 of a first-round series in the Eastern Conference. Detroit squared the series up with a 100-94 win at Madison Square Garden on Monday and will now hope to take control of the series at home. The Pistons won three of four matchups in the regular season between the teams. Isaiah Stewart (knee) is questionable for Detroit after missing Game 2, while New York has no injuries to report.

Tip-off from Little Caesars Arena in Detroit is set for 7 p.m. ET, and the Pistons have now covered the spread in four of their last five against New York. However, the Knicks are 1.5-point favorites in the latest Knicks vs. Pistons odds, after Detroit opened as 1-piont favorites. The over/under for total points scored is 214.5. New York is at -120 on the money line (risk $120 to win $100), with Detroit at +101 (risk $100 to win $101).

Before making any Knicks vs. Pistons picks, check out the NBA predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters the first full week of the 2025 NBA playoffs on a sizzling 156-116 roll on all top-rated NBA picks dating back to last season, returning nearly $4,000. It is also 22-11 (67%) on top-rated NBA against-the-spread picks this season. Anyone following could have seen HUGE returns!

The model has simulated Knicks vs. Pistons 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it also says one side of the spread hits well over 50% of the time!

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